ACTIVE INGREDIENTS AND MOLECULAR TARGETS OF TARAXACUM MONGOLICUM AGAINST HEPATOCELLULAR CARCINOMA: NETWORK PHARMACOLOGY, MOLECULAR DOCKING, AND MOLECULAR DYNAMICS SIMULATION ANALYSIS

Background Taraxacum mongolicum (TM) is a widely used herb.Studies have reported that TM exhibits growth-inhibitory and apoptosis-inducing on multiple tumors, including hepatocellular carcinoma (HCC).The active ingredients, targets, and molecular mechanisms of TM against HCC need to be further elucidated.Methods We identified the active ingredients

The extreme wind speed is a big problem in the design of buildings and structures, especially for unique building and structures.But modern Russian building codes prescribe taking into account regular winds only.Meanwhile, exactly extreme wind speed cost the most damage to constructions.The paper offers a statistic extreme wind speed analyses with

Current increases in not only the intensity and frequency but also the duration of drought events could affect the growth, physiology, and mortality of trees.We experimentally studied the effects of drought duration in combination with fertilization on leaf protezione solare water potential, gas exchange, growth, tissue levels of non-structural car